Santa Ana was a 112-gun three-decker ship of the line of the Spanish Navy, built to plans by Romero Landa. She was the prototype and lead ship of the Santa Ana class, also known as los Meregildos, which were built during the following years at Ferrol and Havana and which formed the backbone of the Spanish Navy - the other ships were the Mejicano, Conde de Regla, Salvador del Mundo, Real Carlos, San Hermenegildo, Reina María Luisa and Príncipe de Asturias. Her dimensions were 213.4 Burgos feet long, 58 feet in the beam and a total tonnage of 2,112 tonnes.