Guglielmo Pallotta (November 13, 1727 – September 21, 1795) was an Italian Roman Catholic Cardinal. Born in Macerata, Marche, he sudied hydraulics and law in Rome and then was ordained priest. Later he became auditor of Cardinal Carlo Rezzonico and served in the Fabric of Saint Peter. In 1773 he was named Treasurer general of the Apostolic Camera. He died in 1795 in Rome.