After the destruction of the USS Enterprise-D in 2371, the Challenger returned from a mission in the Gamma Quadrant to pick up her new first officer, Commander William T. Riker. Commander Riker invoked the official secrets regulation of stardate 7500, took command of the Challenger, and brought Doctor Julian Bashir, Commander Deanna Troi, and Captain James T. Kirk onboard. In 2377, the Challenger was part of a fleet which destroyed Borg Sphere 634. (VOY episode: "Endgame") In 2410, the Challenger was docked inside Earth Spacedock. (STO video game: Delta Rising)