Hyperimmunoglobulin E syndrome, usually referred to as Hyper IgE syndrome on the series, is a group of rare genetic autoimmune disorders which all cause low production of a form of interferon ("gamma"). The most common type is commonly referred to as Job's syndrome (after the biblical figure) or Buckley syndrome (after the doctor to identify it as a separate disorder). Patients are treated with a lifetime course of antibiotics to ward off infections, as well as doses of gamma globulin to treat the skin symptoms.