The submarine conducted seven patrols and sank 38 ships during the war for a total loss of . She operated as part of the Pola Flotilla based in Cattaro. UB-50 surrendered on 16 January 1919 with the remainder of the Pola Flotilla following an order by Admiral Reinhard Scheer to return to port. During her passage through the Straits of Gibraltar, she managed to sink the battleship HMS Britannia. UB-50 was later broken up at Swansea.