The vast majority of sentient beings have some level of conscience. The vast majority of Darksiders learn to ignore their consciences to the point that they are no longer significantly troubled by guilt. This 'callus' effect upon the conscience can be temporarily removed, reminding the target - or beneficiary - of the full extent of his or her misdeeds, and making guilt and shame impossible to ignore. As any Darksider knows, it is possible to work past guilt again. This ability does not work on those who have been afflicted with clinical sociopathy since childhood.