The monastery was founded in 1085 by the Counts of Rück and Tübingen, against the background of the Investiture Controversy and the Hirsau Reforms. The first abbot, Adzelinus, and monks were from Hirsau Abbey. Abbot Fabri was closely involved with the foundation of the University of Tübingen in 1477. In 1493 the high altar was created. The choir stalls by Jörg Syrlin the younger are of a similar date. The Reformation saw the end of the Roman Catholic monastery, from which the monks were expelled in 1535, returning for a short time between 1549 and 1562.