USS Simpson (DD-221/APD-27/AG-97) was a Clemson-class destroyer in the United States Navy during World War II. She was the first ship named for Rear Admiral Edward Simpson. Simpson was laid down on 9 October 1919 by William Cramp and Sons; launched on 28 April 1920; sponsored by Miss Caroline Sterett Simpson, daughter of Rear Admiral Simpson; and commissioned on 3 November 1920, Lieutenant Commander P.T. Berry in command.