Although the inner workings of the technique are unknown, the monomolecular-sized insects involved in the technique, the Hen'ichū, specifically occupy the cardiovascular, nervous, muscular and chakra pathway system, and cover the exterior of the Skeletal System of Mariko's body. Mariko elaborated that because of the abilities of the insects, those specific systems of the body would be the most beneficial for the insects to live in. In doing so, they can change their very nature to strengthen her body in a variety of ways and respond to stimuli at superhuman levels.