USS R-22 (SS-99) was an R-class coastal and harbor defense submarine of the United States Navy. Her keel was laid down on 19 April 1917 by the Lake Torpedo Boat Company in Bridgeport, Connecticut; the R-boats built by Lake Torpedo Boat (R-21 through R-27) are sometimes considered a separate class from those built by Fore River Shipbuilding (R-1 through R-14) and Union Iron Works (R-15 through R-20). She was launched on 23 September 1918 sponsored by Mrs. Erie A. Eklund, and commissioned on 1 August 1919 with Lieutenant Commander Walter S. Hass in command.