Yeshuyab II (reigned 628-644) was a seventh century Christian Catholicos, or patriarch, of Seleucia-Ctesiphon. He played an important role in the ancient Nestorian church of the East, influencing the politics of Christian rule in Persia and seeking to expand the church's influence in east Asia. His reign as patriarch also encompassed the Arab conquest of Seleucia-Ctesiphon, after which the city became part of the Rashidun Islamic Caliphate.