The son of Antoni de Cardona-Anglesola i Centelles and Castellana de Requesens, he was 5th Baron of Bellpuig, Baron of Linyola and Baron of Utxafavá, all three places in Catalonia. Ramón de Cardona was born in Bellpuig, to one of the greatest families in the Crown of Aragon, the Cardona. On 12 December 1502 he was awarded the title of Duke of Soma, taking part in 1505, with the role of admiral, in the capture of Mers-el-Kébir. He died at Naples in 1522. His cenotaph in Bellpuig, executed by Giovanni da Nola, is one of the most outstanding examples of Renaissance art in the region.