Lipnicki was born in Westlake Village, California, son of Joseph and Rhonda (née Rosen) Lipnicki. He has an older sister, Alexis. Lipnicki is Jewish. Lipnicki has appeared and/or spoken at events for the Breast Cancer Research Foundation, Juvenile Diabetes Research Foundation, Starlight Children's Foundation and NBA's Read to Achieve. He is also the international spokesperson for Pediatric Chiropractic and Kids Day American/International. He was named one of "the heroes of 2001" by JDRF for his involvement. Lipnicki, who has four dogs, is also involved in animal rights groups, including Pets & Their Stars and the Nuts for Mutts.