Limerick, in western Ireland was the scene of two sieges during the Irish Confederate Wars. The second and largest of these took place during the Cromwellian conquest of Ireland in 1650–51. Limerick was one the last fortified cities held by an alliance of Irish Confederate Catholics and English Royalists against the forces of the English Parliament. Its garrison, led by Hugh Dubh O'Neill, surrendered to Henry Ireton after a protracted and bitter siege. Over 2,000 soldiers of Cromwell's New Model Army were killed at Limerick, and Henry Ireton, Cromwell's son-in-law died of Plague.