USS R-3 (SS-80) was an R-class coastal and harbor defense submarine of the United States Navy. Her keel was laid down on 11 December 1917 by the Fore River Shipbuilding Company in Quincy, Massachusetts. She was launched on 18 January 1919 sponsored by Mrs. Charles G. McCord, and commissioned on 17 April 1919 at Boston, Massachusetts, with Lieutenant Commander Allen Herschel Guthrie in command.