After the bloody battle against Hades, the goddess Athena and her saints are still recovering when they find themselves face to face with their newest and most formidable foe: the dreadful goddess Artemis. Artemis replaces Athena as the Earth guardian deity and takes over the Sanctuary which she turns Athena saints into her servants. Upon invading the Sanctuary, the Bronze Saints was banish by Artemis and decide to fight the moon goddess in order to rescue their true goddess and free the Earth from Artemis ominous control.