Jessie and Clyde are a breed of Ghouly that first appears in the Study in Chapter 2. Jessie and Clydes are the most powerful breed of attacking ghoulies in the game with the most Energy and damage dealt combined of any ghouly. Jessie and Clydes acts as guards, similar to Medusas, but at a much higher level. Battling with them head-on is a dangerous affair that will most likely end in their favor, if without the aid of Super Soups like One-Hit Wonder! and Weapons like the Soda Pop Gun. Jessie and Clydes have 100 Energy and are the eighteenth to nineteenth ghouly encountered in the game.