Talbot began her acting career appearing as a model in the film, It's a Great Feeling in 1949. She then appeared in such films as Montana, This Side of the Law, This Could be the Night, I Married a Woman, Who's Got the Action, The Movie Murderer, The Day of the Locust, Double Take Serial, The Check Is in the Mail, Take Two and Puppet Master II. In television, she was either a star or co-star of several series, including, Man Against Crime, Search for Tomorrow, Joe & Mabel, Bourbon Street Beat Hot Off the Wire, The Secret Storm, Here We Go Again, Supertrain, General Hospital, and Starting from Scratch, while guest starring on several others, like Hogan's Heroes, Soap, Spider-Man, Goodyear Television Playhouse, Robert Montgomery Presents, Studio One, Mike Hammer, Maverick, Alfred Hitchcock P