Neo-GUILT was created by Acropolis Pharmaceuticals through illegal GUILT research. Unlike Delphi, who use GUILT for terrorism, Acropolis use Neo-GUILT for profit, mainly by selling them to people as steroids. In order to mask this illegal research, Acropolis worked with the Hands of Asclepius to develop a serum to counteract GUILT and Post-GUILT Syndrome, which was created from the same illegal research used in Neo-GUILT development. They are named after four of the Aeons in Gnosticism.