Lee was one of the three finalists for the title role in the 1982 film, Annie, but she lost the role to actress Aileen Quinn and got the role of a dancer instead. She guest-starred on television series including Quincy, M.E, The Incredible Hulk, The Master, The Love Boat, Kids Incorporated, and Highway to Heaven. She had a recurring role as Julia on Who's the Boss? from 1985 to 1987, and later as Brenda Walker on The Hogan Family from 1990 to 1991. As of 2004, Angela Lee Sloan works at a radio station in California.