Fountain of Dreams is set in post-nuclear-war Florida, literally separated from the continental United States of America by heavy bombing. Life on the island of Florida is constantly threatened by the threat of mutation (due to residual radiation) and encounters with local ruffians known as the Killer Clowns, as well as three organized crime factions: the DeSoto Family, the Obeah Orders, and the Bahia Mafia. The player controls a small band of adventurers who set out to find the purifying waters of the legendary "Fountain of Dreams" to stop the spread of mutation.