Myrrah was the Queen of the Locust Horde during both the Locust Civil War and Locust War simultaneously, and then continued in the Lambent Pandemic with the remaining loyal Locust Horde forces. She led her people in an effort hoping to colonize the surface and to destroy the Lambent threat in the Hollow. To accompish this, Myrrah demands the genocide of the Human race after Professor Adam Fenix failed to find a way to destroy the Lambent. Due to her status over her subjects as the Queen, the Locust treat her with the utmost respect, dying for her if necessary. She was killed by Marcus Fenix following the Second Battle of Azura and extinction of the Locust and Lambent due to Adam's Imulsion Countermeasure Weapon.