Meleeing is the most common way to kill grotworms, as they have a very low crush and low stab defence and mediocre slash defence. However, grotworms will immediately launch a magic attack at anyone charging them, making magic protection prayers an option to consider when not at close range. Nevertheless, they are fairly easy to kill using melee and good stats. Considering their damage output they are one of the less difficult enemies in their level grouping. Using soul split, one could heal and stay as long as prayer potion supply allows. Using Guthan's is also a very good way to heal for longer trips, using little or no food. 95+ combat level is recommended. A Guthan's set, Saradomin godsword or an Enchanted excalibur could be a useful healing option.