The Red Queen was a state-of-the-art artificial intelligence used by the Umbrella Corporation. It was created by Umbrella co-founder Doctor Alexander Isaacs using the template of Alicia Marcus, the daughter of Doctor James Marcus, his partner in creating Umbrella. Once Umbrella started expanding Dr Issacs realized he would need help controlling the now vast interests of the Umbrella corporation and so he created the Red Queen. Used to monitor the Hive, the Red Queen was shut down due to her actions during The Hive outbreak. Umbrella eventually reactivated the Red Queen, who supposedly became homicidal towards humanity. In The Final Chapter, the Red Queen aided in the destruction of Umbrella and the saving of what was left of humanity.