The first section of the Great Northern Railway (GNR) - that from Louth to a junction with the Manchester, Sheffield and Lincolnshire Railway at Grimsby - opened on 1 March 1848, but the southern section of the main line, between Maiden Lane and Peterborough, was not opened until August 1850. Holme was one of the original stations, opening with the line on 7 August 1850. On 1 August 1863 Holme became a junction station with the opening of the Ramsey Railway, between Holme and Ramsey. The Ramsey branch closed to passengers on 6 October 1947, and Holme station closed on 6 April 1959.