German submarine U-533 was a Type IXC/40 U-boat of the Nazi German Kriegsmarine during World War II. The submarine was laid down on 17 February 1942 at the Deutsche Werft yard at Hamburg as 'werk' 351, launched on 11 September 1942 and commissioned on 25 November 1942 under the command of Kapitänleutnant Helmut Hennig. After training with the 4th U-boat Flotilla in the Baltic Sea, U-533 was transferred to the 10th flotilla for front-line service on 1 May 1943. She was a member of two wolf packs.