The 2006 Louisville Cardinals football team represented the University of Louisville in the 2006 college football season. The team, led by Bobby Petrino in his fourth year at the school, played their home games in Papa John's Cardinal Stadium. Playing in their second year in the Big East Conference, the team finished the regular season with eleven wins and one loss and were conference champions. They represented the Big East in the 2007 Orange Bowl and with the win ended the season with a 12-1 record. The team ended the season ranked fifth in the nation.