USS Hughes (DD-410) was a World War II-era Sims-class destroyer in the service of the United States Navy, named after Commander Edward Merritt Hughes. Hughes was laid down on 15 September 1937 by Bath Iron Works, Bath, Maine; launched on 17 June 1939; sponsored by Mrs. Edward M. Hughes, widow of Commander Hughes; and commissioned at Boston Navy Yard, on 21 September 1939, Lieutenant Commander Donald J. Ramsey in command.