Demon Blood is a demonic bodily fluid which is a villainous tool found in the Supernatural universe, where it empowers vessels. The Demon Blood is extremely powerful, and is one of the essences of containing Lucifer. The Demon Blood can be obtained by killing a human possessed by a demon, and then draining their blood. Demon Blood is very strong, and gives the host incredible powers, such as white light in the case of Sam Winchester. When infected by Demon Blood, Sam's powers were equivalent, if not the same, as that of Lilith's.