Whitman Mission National Historic Site is a United States National Historic Site located just west of Walla Walla, Washington, at the site of the former Whitman Mission at Waiilatpu. On November 29, 1847, the family of Dr. Marcus Whitman and others were massacred by Native Americans of the Cayuse. The site commemorates Marcus and Narcissa Whitman, the role they played in establishing the Oregon Trail, and the challenges encountered when two cultures meet.