Reisner was born in Indianapolis, Indiana and died in Giza, Egypt. Upon his studies at Jebel Barkal (The Holy Mountain), in Nubia he found the Nubian kings were not buried in the pyramids but outside of them. He also found the skull of a Nubian female (who he thought was a king) which is in the collection of the Peabody Museum of Archaeology and Ethnology at Harvard. Reisner believed that Kerma was originally the base of an Egyptian governor and that these Egyptian rulers evolved into the independent monarchs of Kerma. He met Queen Marie of Romania in Giza.