She attended The Radclyffe School in Chadderton and left with 9 GCSEs (8 A* - C). Dominique starred alongside Paul O'Grady as "Molly" in the 1998 West End production of Annie at the Victoria Palace. Her first major role was as Saffron in the BAFTA winning and heart-warming TV drama Buried Treasure with revered British actor John Thaw. Since September 2007, Dominique has starred as the Emo girl Lauren Valentine on the Channel 4 show Hollyoaks. Jackson left Hollyoaks in August 2010 after she, according to Digital Spy, made a mutual decision to leave in March 2010. Other credits include The Hitchhiker's Guide to the Galaxy, Casualty, Doctors, UGetMe, Welcome to Orty Fou, Conviction, and Little Britain.