"Hide the hydrophobics" is a major goal in Foldit. Getting hydrophobic amino acids buried in the core of the protein is a key to good score. Foldit can highlight exposed hydrophobics, but it's not always possible to hide them all. In Foldit, amino acids are considered either hydrophobic, wanting to hide from water, or hydrophilic, the opposite. Using default view options, the sidechains of hydrophobic amino acids are orange, and the sidechains of hydrophilic amino acids are blue.