HMS Grafton was a 74-gun third rate ship of the line of the Royal Navy, launched on 26 September 1771 at Deptford Dockyard. In 1779 she fought at the head of the British line at the Battle of Grenada, and in 1780 she was part of Rodney's fleet at the Battle of Martinique. From 1792 Grafton was on harbour service, and she was broken up in 1816.