USS Straub (DE-181) was a Cannon-class destroyer escort built for the United States Navy during World War II. She served in the Atlantic Ocean and provided escort service against submarine and air attack for Navy vessels and convoys. She was laid down on 7 June 1943 by the Federal Shipbuilding and Dry Dock Co., at Newark, New Jersey. Sponsored by Mrs. Margaret H. Straub, the escort was launched on 19 September and commissioned on 25 October 1943 at the Brooklyn Navy Yard, Lt. Comdr. James T. Kilbreth, USNR, in command.