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The Journal of Biological Chemistry (often abbreviated JBC) is a scientific journal founded in 1905 and published since 1925 by the American Society for Biochemistry and Molecular Biology. It publishes research in any area of biochemistry or molecular biology, both in print and online, weekly. The Editor is Herbert Tabor. All its articles are available for free on its website. The impact factor of the journal in 2005 was 5.854. In 2005 JBC was the scientific journal that received the largest total number of citations.

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