Android 22 was originally a human on death row, before her execution she swore to vengeance on the jury one of them being Vegets. After she was by a Scientist from the Red Ribbon Army, she sought revenge on the Saiyan Prince. Having his DNA in her, she able to track him down. She fought with the Z-Fighters. She first met her match in Super 18 but she was able to survive the battle by using Gadget's Arm as a shield. She then fought Vegeta at the World Tournament, where she was eventually defeated by him after he became a Super Saiyan 7 for the first time.