Craig Silverman was appointed by Oswell E. Spencer to supervise Eric Lee and Charles Burr in observing Dominic Wesker, one of the last of the Wesker children. Dominic was injected with the prototype virus, just like the other Wesker children before him. Dominic reacted negatively to the virus, but instead of dying, he fell into comatose. Regardless Spencer marked Dominic for termination, and Silverman gave the task to Lee. During the Raccoon City Outbreak, however, Burr discovered that Lee feigned eliminating the child, who turned out to be alive and well as Lee's adopted son, and reported his findings to Silverman.