Deftera is the second strain of GUILT encountered in Under the Knife and Second Opinion. Deftera always attack in pairs, Type A and Type B. A-Deftera are red, and create white-colored smaller tumors, while B-Deftera are blue and create black tumors. When a Type A and Type B collide, the Deftera fruitlessly attempt to consume each other. When two of the same type collide, they drop the host's vitals and create smaller tumors. According to Tyler Chase, Deftera is actually a tumor that replicates its DNA on a rapid scale, making it look like it's moving.