The first station on the site was first opened in 1863 by the Wycombe Railway (later GWR). In 1868 the Aylesbury & Buckingham Railway (later Metropolitan Railway) connected to Aylesbury. The Metropolitan Railway connected from Little Chalfont in 1892, in which the station was rebuilt. The Great Central Railway connected to Aylesbury in 1899 from Annesley Junction just north of Nottingham on their 'London Extension' line to London Marylebone.