Professor Clarke assisted in the creation of the Alpha 100 Series Mechanoid Isaac by creating the robot's hardware around the time the Xorda's emissary came to Earth and was dissected by Kintobor. Whether or not he was involved in the latter event is uncertain. After they used some of the Xorda's technology to create a power matrix for Isaac, the Xorda learned that Dr. Kintobor had dissected their emissary and launched an attack on the planet, which Dr. Kintobor tried to survive in stasis while the rest of the world perished, including Professor Clarke. (StH: #146, #147, #148, #149)