The 22nd Continental Regiment was formed on 1 January 1776 when the 2nd Connecticut Regt (1775) of Spencer's Brigade in the Main Continental Army was re-designated. On 12 August 1776 Spencer's Brigade was re-designated as Parson's Brigade and on 12 November 1776 the brigade was re-assigned to the Highland's Department. The regiment was re-assigned to Mercer's Brigade of the Main Continental Army on the same date. The regiment was disbanded on 31 December 1776 at Peekskill, New York.