In this new era, the difference between humans and Reploids has become nonexistent, and a new combination of "man and machine," called "Humanoids" has emerged. A new series of "Maverick" uprisings begins to occur, which proves to be a dangerous threat since all beings on Earth are now part machine in nature and thus susceptible to the outbreak. Vent/Aile, orphans from a Maverick outbreak that occurred ten years ago, get drawn into the new conflict, along with Girouette, the head of their delivery team.