Set in 22nd Century in New London, Inspector Beth Lestrade of New Scotland Yard is chasing grotesquely deformed French rogue geneticist Martin Fenwick, when she realises that his companion is none other than the 19th century criminal mastermind, Professor James Moriarty. (This is not the original Moriarty but in fact his clone, created from cells taken from his corpse, which Holmes had buried in a Swiss ice cave, near the Reichenbach Falls). Famous biologist Sir Evan Hargreaves (who looks just like Doyle) has just invented cellular rejuvenation. Beth knows that Holmes survived and actually lived to a ripe old age, and further knows that his corpse is preserved in a glass-walled, honey-filled coffin in the basement of New Scotland Yard (This may be both a reference to the legend that Alexan