Dr. Sprague was present when Dr. Gediman surgically removed the infant Cloned Queen from Ripley 8, and subsequently took over when Dr. Wren elected to keep Ripley 8 alive for study. As he attempted to close the incision in her chest, she awoke and badly broke his arm, giving him numerous compound fractures before Wren managed to sedate her again. He was carried away for emergency surgery to repair the damage. Sprague was later taken by the Cloned Xenomorphs when they escaped and implanted with a Chestburster, dying when the creature burst from his chest.