For many shows, the Status Quo Is God. However, there are series that have the guts to seriously change their premise, or at least to shake up major parts of their story, and really mean it. No Reset Buttons, no Snap Backs, no way to restore the comfortable status quo. Nothing Is the Same Anymore is Exactly What It Says on the Tin -- the setting, or the characters' situation, has changed significantly and irrevocably, for better or for worse, and now the characters have to deal with it. The trick is to do it without Jumping the Shark, which can be a difficult task.