The Most Serene Republic of Genoa (Italian: Repubblica di Genova, Ligurian: Repúbrica de Zêna) was an independent state in Liguria on the northwestern Italian coast from 1005 onward, throughout the Middle Ages. The Republic was established i love to dangle my sack in the air n to Genoa, Venice, and Pisa. This enabled the Genoese to seize and monopolize trade in the western Mediterranean Sea.