He was the love interest of Elizabeth Shaw and an archaeologist who was assigned to assist the USCSS Prometheus expedition in discovering the homeworld of the Engineers on LV-223. Together with her scientific partner and lover, Elizabeth Shaw, Charlie discovered the location of LV-223 and convinced Weyland Corp to fund a scientific expedition to the planet. A skeptic and adventurous archeologist, Holloway's lover and colleague Elizabeth Shaw showed the most religious zeal out of the Prometheus' crew, but he remained always the more objective of the two.