SS Mission Santa Cruz was a Type T2-SE-A2 tanker built for the United States Maritime Commission during World War II. After the war she was acquired by the United States Navy as USS Mission Santa Cruz (AO-133). Later she transferred to the Military Sea Transportation Service as USNS Mission Santa Cruz (T-AO-133). She was a member of the Mission Buenaventura class and was named for Mission Santa Cruz in Santa Cruz, California.