Try to complete each puzzle without help first. Most of the puzzles should take only a couple of minutes. If you get stuck, use "Reset Puzzle" from Actions menu in the lower left and try again. If you're having problems, you'll find tips below. Just click on the icon for the puzzle you're stuck on. There are tips and techniques for each puzzle, plus a a video provided by Foldit player Madde. There are also some general tips on how to navigate in Foldit.